Unimod, View record [
Accession #: 1001
]
| Accession # |
1001 |
PSI-MS Name |
|
Interim Name |
AHA-Alkyne-KDDDD |
| Description |
Azidohomoalanine (AHA) bound to DDDDK-propargylglycine-NH2 (alkyne) |
| Composition |
H(37) C(26) N(11) O(14) S(-1) |
Monoisotopic |
695.280074 |
Average |
695.5723 |
| Site |
M |
Position |
Anywhere |
Classification |
Chemical derivative |
| Source |
Journal |
Reference |
Dieterich DC et al., (2007) Labeling, detection and identification of newly synthesized proteomes with bioorthogonal non-canonical amino acid tagging. Nature Protocols 2(3): 532-40. |
| Notes |
Methionine (C5H11NO2S) is substituted in culture with azidohomoalanine (AHA - C4H8N4O2). The azide group reacts with the alkyne group DDDDK-propargylglycine-NH2. As a result the side chain of methionine (C3H7S) is substituted by C29H44N11O14. |
| Curator |
BThomas |
Last Modified |
2010-10-03 13:44:40 |
Verified |
No |
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