Unimod, View record [
Accession #: 514
]
Accession # |
514 |
PSI-MS Name |
PropylNAGthiazoline |
Interim Name |
propyl-NAG-thiazoline |
Description |
propyl-1,2-dideoxy-2\'-methyl-alpha-D-glucopyranoso-[2,1-d]-Delta2\'-thiazoline |
Composition |
H(14) C(9) N O(4) S |
Monoisotopic |
232.064354 |
Average |
232.2768 |
Site |
C |
Position |
Anywhere |
Classification |
Chemical derivative |
Source |
PubMed PMID |
Reference |
15795231 |
Notes |
In a recent publication (see reference), we have shown that family 84 glycoside hydrolases contain a deep pocket beneath the 2-acetamido group of its substrate (N-acetyl-glucosamine). With this strucual feature in mind, we have designed a specific inhibitor that contains a chloride group appended to the end of the propyl chain on a known inhibitor termed propyl-NAG-thiazoline. We have shown kinetically that this molecule is a potent suicide inhibitor of this enzyme famiy and now wish to know the precise residue which is acting as the nucleophile to dispace the choride atom. We have included all residues that are in the vacinity of the chloride atom that could potentially act in a nucleophilic manner. |
Curator |
mmacaule |
Last Modified |
2015-05-01 13:33:58 |
Verified |
No |
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