GIST acetyl light
PT and GIST acetyl light
O-acetyl
14730666
PubMed PMID
15350136
PubMed PMID
AA0055
RESID
IonSource acetylation tutorial
Misc. URL
http://www.ionsource.com/Card/acetylation/acetylation.htm
Chemical Reagents for Protein Modification 3rd edition, pp 215-221, Roger L. Lundblad, CRC Press, New York, N.Y., 2005
Book
11999733
PubMed PMID
AA0043
RESID
AA0044
RESID
AA0354
RESID
AA0045
RESID
AA0056
RESID
AA0046
RESID
AA0051
RESID
AA0052
RESID
AA0364
RESID
AA0041
RESID
AA0049
RESID
AA0048
RESID
AA0047
RESID
12175151
PubMed PMID
11857757
PubMed PMID
AA0042
RESID
AA0050
RESID
AA0053
RESID
AA0054
RESID
ACET
FindMod
PNAS 2006 103: 18574-18579
Journal
http://dx.doi.org/10.1073/pnas.0608995103
AA0100
RESID
AA0099
RESID
AA0098
RESID
AA0097
RESID
AA0096
RESID
AA0095
RESID
AA0094
RESID
AA0093
RESID
AA0092
RESID
AA0091
RESID
AA0090
RESID
AA0089
RESID
AA0081
RESID
AA0082
RESID
AA0083
RESID
AA0084
RESID
AA0085
RESID
AA0086
RESID
AA0087
RESID
AA0088
RESID
AMID
FindMod
AA0117
RESID
BIOT
FindMod
Carboxyamidomethylation
Creasy, D. M., Cottrell, J. S., Proteomics 2 1426-34 (2002)
Journal
11510821
PubMed PMID
Boja, E. S., Fales, H. M., Anal. Chem. 73 3576-82 (2001)
Journal
12422359
PubMed PMID
AA0343
RESID
12203680
PubMed PMID
AA0332
RESID
IonSource carbamylation tutorial
Misc. URL
http://www.ionsource.com/Card/carbam/carbam.htm
10978403
PubMed PMID
Carbamylation is an irreversible process of non-enzymatic modification of proteins by the breakdown products of urea isocyanic acid reacts with the N-term of a proteine or side chains of lysine and arginine residues
Hydroxylethanone
Carboxymethylation
Protein which is post-translationally modified by the de-imination of one or more arginine residues; Peptidylarginine deiminase (PAD) converts protein bound to citrulline
Convertion of glycosylated asparagine residues upon deglycosylation with PGNase F in H2O
phenyllactyl from N-term Phe
Citrullination
IonSource tutorial
Misc. URL
http://www.ionsource.com/Card/Deamidation/deamidation.htm
CITR
FindMod
FLAC
FindMod
AA0128
RESID
AA0214
RESID
6838602
PubMed PMID
15700232
PubMed PMID
DEAM
FindMod
10504701
PubMed PMID
Gygi S.P., et. al. Nat Biotechnol. 1999 Oct;17(10):994-9
Journal
10504701
PubMed PMID
Gygi S.P., et. al. Nat Biotechnol. 1999 Oct;17(10):994-9
Journal
Cyanogen bromide (CNBr) cleavage converts the C-term Met to either homoserine or homoserine lactone, depending on pH.
Donald Voet, Judith G. Voet (1995): Biochemistry; p 115
Book
Cyanogen bromide (CNBr) cleavage converts the C-term Met to either homoserine or homoserine lactone, depending on pH.
Structure
Misc. URL
http://www.chemsoc.org/exemplarchem/entries/2002/proteomics/images/icat_reagent.gif
Molecular & Cellular Proteomics 2:428-442, 2003
Journal
http://www.mcponline.org/cgi/content/full/2/7/428
Structure
Misc. URL
http://www.chemsoc.org/exemplarchem/entries/2002/proteomics/images/icat_reagent.gif
Molecular & Cellular Proteomics 2:428-442, 2003
Journal
http://www.mcponline.org/cgi/content/full/2/7/428
Dimethylacrylamide, DMA
Krutzsch and Inman, Analytical Biochemistry, 209, 109-116, (1993)
Journal
Galvani et.al. (2000) Electrophoresis vol 22 p2046-p2074
Journal
8465942
PubMed PMID
11465505
PubMed PMID
Pierce EZ-Link PEO-Iodoacetyl Biotin
12038753
PubMed PMID
J. Biol. Chem., Vol. 278, Issue 7, 4500-4509, February 14, 2003
Journal
http://www.jbc.org/cgi/content/full/278/7/4500#F1
15253424
PubMed PMID
Rare
Rare
Usually don't see beta elimination of phosphate
Rare
IonSource
Misc. URL
http://www.ionsource.com/Card/phos/phos.htm
AA0037
RESID
AA0033
RESID
AA0038
RESID
AA0039
RESID
AA0222
RESID
PHOS
FindMod
AA0034
RESID
AA0036
RESID
AA0035
RESID
Protein which is posttranslationally modified by the attachment of at least one phosphate group usually on serine, threonine or tyrosine residues, but also on aspartic acid or histidine residues.
beta-elimination
beta-elimination
beta-elimination
Pyro-carboxymethyl as a delta from Carboxymethyl-Cys
didehydroalanine
C-terminal imide
Prompt loss of phosphate from phosphorylated residue
D-Succinimide
DHAS
FindMod
AA0303
RESID
AA0302
RESID
AA0181
RESID
AA0182
RESID
DHB
FindMod
9276974
PubMed PMID
Carboxymethyl-Cys cyclization (N-terminus)
Carbamidomethyl-Cys cyclization (N-terminus)
12643538
PubMed PMID
J. Proteome Res. 1, 181-187 (2002)
Journal
Cyclisation of N-term Carbamidomethyl-Cys or Carboxymethyl-Cys. The delta is relative to Cys. For a delta relative to alkylated Cys, see Ammonia-loss and Dehydrated.
AA0031
RESID
Miller et.al. Arch. Biochem. Biophy. (1993) 301, 41-52.
Journal
8442665
PubMed PMID
PYRE
FindMod
AA0031
RESID
PYRR
FindMod
10446193
PubMed PMID
Sherman, N. E., Yates, N. A., Shabanowitz, J., Hunt, D. F., Jeffery, W. A., Bartlet-Jones, M., and Pappin, D. J. C. (1995) Proceedings of the 43rd ASMS Conference on Mass Spectrometry and Allied Topics, May 21-26, 1995, Atlanta, GA
Journal
Proton replaced by sodium cation
11760118
PubMed PMID
methyl ester
METH
FindMod
AA0318
RESID
AA0338
RESID
AA0064
RESID
AA0061
RESID
AA0063
RESID
AA0065
RESID
AA0069
RESID
AA0336
RESID
AA0305
RESID
AA0272
RESID
AA0076
RESID
AA0071
RESID
AA0070
RESID
AA0073
RESID
AA0234
RESID
AA0273
RESID
AA0317
RESID
AA0337
RESID
AA0299
RESID
AA0072
RESID
11875433
PubMed PMID
AA0105
RESID
Cysteine sulfenic acid
Proline oxidation to glutamic semialdehyde
Hydroxyglycine derivative in amidation pathway
HYDR
FindMod
AA0322
RESID
11212008
PubMed PMID
11120890
PubMed PMID
DOPA
FindMod
CSEA
FindMod
14661084
PubMed PMID
AA0026
RESID
Berlett, Barbara S.; Stadtman, Earl R. Journal of Biological Chemistry (1997), 272(33), 20313-20316.
Journal
15569593
PubMed PMID
AA0205
RESID
AA0215
RESID
Lagerwerf FM, van de Weert M, Heerma W, Haverkamp J, Rapid Commun Mass Spectrom. 1996;10(15):1905-10
Journal
AA0029
RESID
AA0030
RESID
9004526
PubMed PMID
AA0028
RESID
11461766
PubMed PMID
AA0027
RESID
AA0235
RESID
AA0146
RESID
14661085
PubMed PMID
12781462
PubMed PMID
2057999
PubMed PMID
DIMETH
FindMod
AA0311
RESID
AA0068
RESID
14570711
PubMed PMID
AA0067
RESID
12964758
PubMed PMID
AA0075
RESID
AA0066
RESID
12590383
PubMed PMID
AA0074
RESID
AA0062
RESID
Role of arginine and its methylated derivatives in cancer biology and treatment
Misc. URL
http://www.cancerci.com/content/1/1/3
J. Hirota et. al., Rapid Commun. Mass Spectrom., 17 371-6 (2003)
Journal
TRIMETH
FindMod
RESID gives the delta as 43 Da?
Methyl methanethiosulfonate
MMTS
J. A. Kowalak and K. A. Walsh, Protein Science (1996) 5: 1625-1632
Journal
AA0232
RESID
TRC data sheet
Misc. URL
http://www.trc-canada.com/white_papers.lasso
Applied Biosystems iTRAQ(TM) Reagents Chemistry Reference Guide Part Number 4351918 Rev. A
Misc. URL
http://docs.appliedbiosystems.com/pebiodocs/04351918.pdf
AA0320
RESID
8844851
PubMed PMID
AA0101
RESID
BMTH
FindMod
Sulfitolysis
AA0362
RESID
AA0361
RESID
SULF
FindMod
AA0171
RESID
Medzihradszky et al., Mol. Cell. Proteomics 2004, 3, 429-440
Journal
14752058
PubMed PMID
AA0172
RESID
glycation
glycation
Fructose
Glucose
Galactose
Mannose
GLUC
FindMod
15279557
PubMed PMID
AA0152
RESID
AA0157
RESID
AA0327
RESID
AA0217
RESID
CMAN
FindMod
PDOC00168
Prosite
AA0118
RESID
LIPY
FindMod
3522581
PubMed PMID
This group is normally a substituent on N6 of a lysine residue of an enzyme or other protein
GLCN
FindMod
AA0151
RESID
AA0154
RESID
3086323
PubMed PMID
AA0155
RESID
The amine derivative of a hexose formed by replacing a hydroxyl group with an amino group.(+acetyl group)
15609361
PubMed PMID
AA0102
RESID
FARN
FindMod
PDOC00008
Prosite
AA0059
RESID
AA0307
RESID
AA0078
RESID
MYRI
FindMod
Biochemistry; D.Voet and J.G.Voet WILEY(p728)
Book
AA0119
RESID
PLP
FindMod
The co-enzyme derivative of vitamin B6. Forms Schiff\'s bases of substrate amino acids during catalysis of transamination, decarboxylation and racemisation reactions.
AA0080
RESID
AA0079
RESID
AA0106
RESID
AA0077
RESID
PALM
FindMod
AA0339
RESID
AA0060
RESID
Palmitoylation is a post-translational modification that consists in the addition of a 16 carbons fatty acid, palmitate, to a cysteine residue through the creation of a thioester link.
AA0104
RESID
15609361
PubMed PMID
GERA
FindMod
AA0150
RESID
PPAN
FindMod
Protein which contains at least one phosphopantetheine as the prosthetic group. In acyl carrier proteins (ACP) for example, it serves as a \'swinging arm\' for the attachment of activated fatty acid and amino-acid groups.
AA0143
RESID
Structure
Misc. URL
http://www.aw-bc.com/mathews/EF/FAD.GIF
AA0144
RESID
AA0145
RESID
AA0221
RESID
FAD
FindMod
10356335
PubMed PMID
homoarginine
11078590
PubMed PMID
ASMS 2001 abstract
Misc. URL
http://www.indiana.edu/~reillyjp/ASMS2001posters/beardsley_poster.pdf
11821862
PubMed PMID
11085420
PubMed PMID
Anal. Biochem. 287, p110-117, 2000
Journal
Specific for sidechain of lysine. Does not modify the N-termini except for glycine at a slower rate than the side chain of lysine.
11327326
PubMed PMID
Poli G, Schaur RJ., IUBMB Life 2000 Oct-Nov;50(4-5):315-21
Journal
A lipid-type modification. HNE forms a Michael addition product on Cysteine, Histidine and Lysines. Unusually, it doesn\'t replace a hydrogen on the amino acid side chain.
glucuronosyl
AA0291
RESID
AA0058
RESID
Lin, T.S. Kolattukudy, P.E., Eur. J. Biochem. 106, 341-351, 1980
Journal
7398618
PubMed PMID
The addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. Addition of glucuronic acid. Observed for N-term G
3083866
PubMed PMID
8344916
PubMed PMID
AA0229
RESID
GLUT
FindMod
N-trideuteriumacetoxy
11857757
PubMed PMID
11999733
PubMed PMID
12175151
PubMed PMID
Controlling Deuterium isotope effects in comparative proteomics. Zhang, Roujian; Sioma, Cathy S.; Thompson, Robert A.; Xiong, Li; Regnier, Fred E.. Department of Chemistry, Purdue University, West Lafayette, IN, USA. Analytical Chemistry (2
Journal
Global internal standard technology for comparative proteomics. Chakraborty, Asish; Regnier, Fred E.. Department of Chemistry, Purdue University, West Lafayette, IN, USA. Journal of Chromatography, A (2002), 949(1-2), 173-184.
Journal
Comparative proteomics based on stable isotope labeling and affinity selection. Regnier, Fred E.; Riggs, Larry; Zhang, Roujian; Xiong, Li; Liu, Peiran; Chakraborty, Asish; Seeley, Erin; Sioma, Cathy; Thompson, Robert A. Department of Chemistry, Pu
Journal
Comparative proteomics based on stable isotope labeling and affinity selection. Regnier, Fred E.; Riggs, Larry; Zhang, Roujian; Xiong, Li; Liu, Peiran; Chakraborty, Asish; Seeley, Erin; Sioma, Cathy; Thompson, Robert A. Department of Chemistry, Pu
Journal
12175151
PubMed PMID
11999733
PubMed PMID
11857757
PubMed PMID
Global internal standard technology for comparative proteomics. Chakraborty, Asish; Regnier, Fred E.. Department of Chemistry, Purdue University, West Lafayette, IN, USA. Journal of Chromatography, A (2002), 949(1-2), 173-184.
Journal
Controlling Deuterium isotope effects in comparative proteomics. Zhang, Roujian; Sioma, Cathy S.; Thompson, Robert A.; Xiong, Li; Regnier, Fred E.. Department of Chemistry, Purdue University, West Lafayette, IN, USA. Analytical Chemistry (2
Journal
Comparative proteomics based on stable isotope labeling and affinity selection. Regnier, Fred E.; Riggs, Larry; Zhang, Roujian; Xiong, Li; Liu, Peiran; Chakraborty, Asish; Seeley, Erin; Sioma, Cathy; Thompson, Robert A. Department of Chemistry, Pu
Journal
Global internal standard technology for comparative proteomics. Chakraborty, Asish; Regnier, Fred E.. Department of Chemistry, Purdue University, West Lafayette, IN, USA. Journal of Chromatography, A (2002), 949(1-2), 173-184.
Journal
Controlling Deuterium isotope effects in comparative proteomics. Zhang, Roujian; Sioma, Cathy S.; Thompson, Robert A.; Xiong, Li; Regnier, Fred E.. Department of Chemistry, Purdue University, West Lafayette, IN, USA. Analytical Chemistry (2
Journal
11857757
PubMed PMID
12175151
PubMed PMID
11999733
PubMed PMID
N-(4-trimethylammoniumbutanoxy)-NHS
Comparative proteomics based on stable isotope labeling and affinity selection. Regnier, Fred E.; Riggs, Larry; Zhang, Roujian; Xiong, Li; Liu, Peiran; Chakraborty, Asish; Seeley, Erin; Sioma, Cathy; Thompson, Robert A. Department of Chemistry, Pu
Journal
11857757
PubMed PMID
Comparative proteomics based on stable isotope labeling and affinity selection. Regnier, Fred E.; Riggs, Larry; Zhang, Roujian; Xiong, Li; Liu, Peiran; Chakraborty, Asish; Seeley, Erin; Sioma, Cathy; Thompson, Robert A. Department of Chemistry, Pu
Journal
11857757
PubMed PMID
Comparative proteomics based on stable isotope labeling and affinity selection. Regnier, Fred E.; Riggs, Larry; Zhang, Roujian; Xiong, Li; Liu, Peiran; Chakraborty, Asish; Seeley, Erin; Sioma, Cathy; Thompson, Robert A. Department of Chemistry, Pu
Journal
11857757
PubMed PMID
Comparative proteomics based on stable isotope labeling and affinity selection. Regnier, Fred E.; Riggs, Larry; Zhang, Roujian; Xiong, Li; Liu, Peiran; Chakraborty, Asish; Seeley, Erin; Sioma, Cathy; Thompson, Robert A. Department of Chemistry, Pu
Journal
11857757
PubMed PMID
Controlling Deuterium isotope effects in comparative proteomics. Zhang, Roujian; Sioma, Cathy S.; Thompson, Robert A.; Xiong, Li; Regnier, Fred E.. Department of Chemistry, Purdue University, West Lafayette, IN, USA. Analytical Chemistry (2
Journal
Comparative proteomics based on stable isotope labeling and affinity selection. Regnier, Fred E.; Riggs, Larry; Zhang, Roujian; Xiong, Li; Liu, Peiran; Chakraborty, Asish; Seeley, Erin; Sioma, Cathy; Thompson, Robert A. Department of Chemistry, Pu
Journal
12175151
PubMed PMID
11857757
PubMed PMID
AA0130
RESID
Controlling Deuterium isotope effects in comparative proteomics. Zhang, Roujian; Sioma, Cathy S.; Thompson, Robert A.; Xiong, Li; Regnier, Fred E.. Department of Chemistry, Purdue University, West Lafayette, IN, USA. Analytical Chemistry (2
Journal
Comparative proteomics based on stable isotope labeling and affinity selection. Regnier, Fred E.; Riggs, Larry; Zhang, Roujian; Xiong, Li; Liu, Peiran; Chakraborty, Asish; Seeley, Erin; Sioma, Cathy; Thompson, Robert A. Department of Chemistry, Pu
Journal
11857757
PubMed PMID
12175151
PubMed PMID
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